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Alexei Vyssotski

Affiliation   Institute of Neuroinformatics, University of Zürich / ETH Zurich, Switzerland.

Professional address:
Winterthurerstrasse 190
CH-8057 Zürich
Tel: +41 79 756 5177
Fax:+41 44 635 3053
Scientific interests:   Behavioral Neuroscience, animal behavior and neurophysiology under naturalistic conditions
Technical development:




Basics of instrumentation, measurement and analysis
Fall semester, INI-502, 402-0821-00



Sept '89 - May '95

Graduated at the Moscow Institute of Physics & Technology, faculty of Physical & Chemical Biology, division “Ecology”.
Sept '95 - Oct '98 Doctorand at the Institute of Normal Physiology of the Moscow Medical Academy, Research in long-term memory formation in chicks, mice and rats using nootropics (with Prof. K.V. Anokhin).
Nov '98 - Sept '01 Postdiplomand at the Institute of Anatomy, University Zurich (with Prof. H.-P. Lipp).
Sept '01 Ph. D. in Physiology, Moscow. Title of the thesis: “Comparative investigation of mechanisms of long-term memory formation using nootropics and genetically modified animal strains”.
Sept '01 - Aug '07 Postdoctoral researcher at the Institute of Anatomy, University Zurich . Research in animal behavior, orientation, natural selection and electrophysiology (with Prof. H.-P. Lipp).
Sept '07 - Oct '08 Research fellow at the Institute of Anatomy, University Zurich. Research in animal navigation and electrophysiology of avian brain, sharing responsibility of IT support of the Institute.
Since Apr '09

Research fellow, Senior scientist at the Institute of Neuroinformatics, University of Zurich / ETH Zurich. Research in electrophysiology of avian brain.

Publications :  
2019 Ma Y, Miracca G, Yu X, Harding EC, Miao A, Yustos R, Vyssotski AL, Franks NP, Wisden W. (2019) Galanin Neurons Unite Sleep Homeostasis and α2-Adrenergic Sedation. Curr Biol. 2019 Oct 7;29(19):3315-3322.e3. doi: 10.1016/j.cub.2019.07.087.
  Gent TC, Vyssotski AL, Detotto C, Isler S, Wehrle M and Bettschart-Wolfensberger Rl. (2019) Is xenon a suitable euthanasia agent for mice?, Veterinary Anaesthesia and Analgesia, https://doi.org/10.1016/j.vaa.2019.04.002
  Kendall-Bar JM, Vyssotski AL, Mukhametov LM, Siegel JM, Lyamin OI. (2019) Eye state asymmetry during aquatic unihemispheric slow wave sleep in northern fur seals (Callorhinus ursinus). PLoS One. 2019 May 22;14(5):e0217025. doi: 10.1371/journal.pone.0217025. [S1_Table] [S2_Table] [S3_Table] [S4_File]
  Allocca G, Ma S, Martelli D, Cerri M, Del Vecchio F, Bastianini S, Zoccoli G, Amici R, Morairty SR, Aulsebrook AE, Blackburn S, Lesku JA, Rattenborg NC, Vyssotski AL, Wams E, Porcheret K, Wulff K, Foster R, Chan JKM, Nicholas CL, Freestone DR, Johnston LA and Gundlach AL (2019) Validation of ‘Somnivore’, a Machine Learning Algorithm for Automated Scoring and Analysis of Polysomnography Data. Front. Neurosci. 13:207. doi: 10.3389/fnins.2019.00207 

Yu X, Ma Y, Harding EC, Yustos R, Vyssotski AL, Franks NP,Wisden W (2019) Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness. Sleep. 2019 Feb 5. doi: 10.1093/sleep/zsz031.

  Detotto C, Isler S, Wehrle M, Vyssotski AL, Bettschart-Wolfensberger R, Gent TC (2019) Nitrogen gas produces less behavioural and neurophysiological excitation than carbon dioxide in mice undergoing euthanasia. PLoS One 2019 Jan 31;14(1):e0210818. doi: 10.1371/journal.pone.0210818.
  Yu X, Li W, Ma Y, Tossell K, Harris JJ, Harding EC, Ba W, Miracca G, Wang D, Li L, Guo J, Chen M, Li Y, Yustos R, Vyssotski AL, Burdakov D, Yang Q, Dong H, Franks NP, Wisden W. (2019) GABA and glutamate neurons in the VTA regulate sleep and wakefulness. Nat Neurosci. 2019 Jan;22(1):106-119. doi: 10.1038/s41593-018-0288-9. Epub 2018 Dec 17. [Supplemental Information]
2018 Tisdale RK, Lesku JA, Beckers GJL, Vyssotski AL, Rattenborg NC. (2018) The low-down on sleeping down low: pigeons shift to lighter forms of sleep when sleeping near the ground. J Exp Biol. 2018 Oct 4;221(Pt 19). pii: jeb182634. doi: 10.1242/jeb.182634. [Supplemental Information]
  Müller MS, Vyssotski AL, Yamamoto M, Yoda K (2018) Individual differences in heart rate reveal a broad range of autonomic phenotypes in a free-living seabird population. J Exp Biol. 2018 Aug 20. pii: jeb.182758. doi: 10.1242/jeb.182758.
  Harding EC, Yu X, Miao A, Andrews N, Ma Y, Ye Z, Lignos L, Miracca G, Ba W, Yustos R,Vyssotski AL, Wisden W, Franks NP (2018) A neuronal hub binding sleep initiation and body cooling in response to a warm external stimulus. Curr Biol. 28, 1-11, July 23, doi.org/10.1016/j.cub.2018.05.054. [Supplemental Information]
  Lyamin OI, Kosenko PO, Korneva SM, Vyssotski AL, Mukhametov LM, Siegel JM. (2018) Fur Seals Suppress REM Sleep for Very Long Periods without Subsequent Rebound. Curr Biol. 2018 Jun 18;28(12):2000-2005.e2. doi: 10.1016/j.cub.2018.05.022. [Supplemental Information]
  Gent TC, Detotto C, Vyssotski AL, Bettschart-Wolfensberger R (2018) Epileptiform activity during inert gas euthanasia of mice. PLoS ONE 13(4), Apr 19: e0195872. https://doi.org/10.1371/ journal.pone.0195872
  Gelegen C, Miracca G, Ran MZ, Harding EC, Ye Z, Yu X, Tossel K, Houston CM, Yustos R, Hawkins ED, Vyssotski AL, Dong HL, Wisden W, and Franks N. (2018) Excitatory pathways from the lateral habenula enable propofor-induced sedation. Curr Biol. 28, 1-8, Feb 19, https://doi.org/10.1016/j.cub.2017.12.050 [Supplemental Information]

Nair J, Klaassen AL, Arato J, Vyssotski AL, Harvey M, Rainer G. (2018) Basal forebrain contributes to default mode network regulation. Proc Natl Acad Sci U S A. 2018 Jan 23. pii: 201712431. doi: 10.1073/pnas.1712431115. [Supporting Information]

2017 EFSA AHAW Panel (EFSA Panel on Animal Health and Welfare), More S, Bicout D, Bøtner A, Butterworth A, Calistri P, Depner K, Edwards S, Garin-Bastuji B, Good M, Gortazar Schmidt C, Miranda MA, Nielsen SS, Sihvonen L, Spoolder H, Willeberg P, Raj M, Thulke H-H, Velarde A, Vyssotski A, Winckler C, Cortiñas Abrahantes J, Garcia A, Muñoz Guajardo I, Zancanaro G and Michel V. (2017) Scientific Opinion on the low atmospheric pressure system for stunning broiler chickens. EFSA Journal 2017;15(12):5056, 86 pp. https://doi.org/10.2903/j.efsa.2017.5056
  Scriba MF, Henry I, Vyssotski AL, Mueller JC, Rattenborg NC, Roulin A. (2017) Ultradian Rhythmicity in Sleep-Wakefulness Is Related to Color in Nestling Barn Owls. J Biol Rhythms. 2017 Aug 1. doi: 10.1177/0748730417722250
  Müller MS, Vyssotski AL, Yamamoto M, Yoda K. (2017) Heart rate variability reveals that a decrease in parasympathetic ('rest-and-digest') activity dominates autonomic stress responses in a free-living seabird. Comp Biochem Physiol A Mol Integr Physiol. 2017 Jul 23. doi: 10.1016/j.cbpa.2017.07.007. [Supplemental Data]
  Tisdale RK, Vyssotski AL, Lesku JA, Rattenborg NC. (2017) Sleep-Related Electrophysiology and Behavior of Tinamous (Eudromia elegans): Tinamous Do Not Sleep Like Ostriches. Brain Behav Evol. 2017 Jul 7. doi: 10.1159/000475590
  Scriba MF, Dreiss AN, Henry I, Be´ziers P, Ruppli C, Ifrid E, Ducouret P, Da Silva A, Monstiers B, Vyssotski AL, Rattenbord NC, Roulin A. (2017) Nocturnal, diurnal and bimodal patterns of locomotion, sibling interactions and sleep in nestling Barn Owls. J. Ornithol. 2017 May 8. doi: 10.1007/s10336-017-1458-3. [Supplemental Data]
  Jovalekic A, Cave-Lopez S, Canopoli A, Ondracek JM, Nager A, Vyssotski AL, Hahnloser RHR. (2017) A lightweight feedback-controlled microdrive for chronic neural recordings. J. Neural Eng. 2017 Apr;14(2):026006. doi: 10.1088/1741-2552/aa5848. Epub 2017 Jan 10. [Supplemental Data]
  Franklin TB, Silva BA, Perova Z, Marrone L, Masferrer ME, Zhan Y, Kaplan A, Greetham L, Verrechia V, Halman A, Pagella S, Vyssotski AL, Illarionova A, Grinevich V, Branco T, Gross CT. (2017) Prefrontal cortical control of a brainstem social behavior circuit. Nat Neurosci. 2017 Jan 9. doi: 10.1038/nn.4470. [Supplemental Data]
2016 Nair J, Klaassen AL, Poirot J, Vyssotski A, Rasch B, Rainer G. (2016) Gamma band directional interactions between basal forebrain and visual cortex during wake and sleep startes. J Physiol Paris. 2016 Nov 29. pii: S0928-4257(16)30033-X. doi: 10.1016/j.jphysparis.2016.11.011
  Uygun DS, Ye Z, Zecharia AY, Harding EC, Yu X, Yustos R, Vyssotski AL, Brickley SG, Franks NP, Wisden W. (2016) Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons. J Neurosci. 2016 Nov 2;36(44):11171-11184.
  Rattenborg NC, Voirin B, Cruz SM, Tisdale R, Dell'Omo G, Lipp HP, Wikelski M, Vyssotski AL. (2016) Evidence that birds sleep in mid-flight. Nat Commun. 2016 Aug 3;7:12468. doi: 10.1038/ncomms12468. [Supplementary Information] [Supplementary Movie 1 (10 min Flight)] [Supplementary Movie 2 (Frigatebird 13)] [Supplementary Movie 3 (Frigatebird 10)] [Supplementary Movie 4 (Frigatebird Drop)]
2015 Yu X. Ye Z, Huston CM, Zecharia AY, Ma Y, Zhang Z, Uygun DS, Parker S, Vyssotski AL, Yustos R, Franks NP, Brickley SG, Wisden W (2015) Wakefulness is governed by GABA and histamine cotransmission. Neuron. http://dx.doi.org/10.1016/j.neuron.2015.06.003 [Supplemental Data]
  Zhang Z, Ferretti V, Güntan İ, Moro A, Steinberg EA, Ye Z, Zecharia AY, Yu X, Vyssotski AL, Brickley SG, Yustos R, Pillidge ZE, Harding EC, Wisden W, Franks NP (2015) Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists. Nat Neurosci. 2015 Apr;18(4):553-61. doi: 10.1038/nn.3957. [Supplemental Data]
2014 Yu X, Zecharia A, Zhang Z, Yang Q, Yustos R, Jager P, Vyssotski AL, Maywood ES, Chesham JE, Ma Y, Brickley SG, Hastings MH, Franks NP, Wisden W (2014) Circadian Factor BMAL1 in Histaminergic Neurons Regulates Sleep Architecture. Curr Biol. 24(23): 2838-2844. [Supplemental Data]
  Anisimov VN, Herbst JA, Abramchuk AN, Latanov AV, Hahnloser RH, Vyssotski AL (2014) Reconstraction of vocal interactons in a group of small songbirds. Nat Methods. 2014 Nov; 11(11):1135-7. doi: 10.1038/nmeth.3114. [Supplementary Text] [Supplementary Video 1 (4 Males)] [Supplementary Video 2 (Juvenile 40dph Backpack)] [Supplementary Video 3 (Juvenile Flight Backpack)] [Supplementary Video 4 (Juvenile 39dph)] [Supplementary Video 5 (Male Female)] [Supplementary Software] [Journal Cover] [In This Issue] [The Author File] [Supplementary Software updated 18.09.2016] [Supplementary Software updated 27.10.2017]
  Baker R, Gent TC, Yang Q, Parker S, Vyssotski AL, Wisden W, Brickley SG, Franks NP. (2014) Altered Activity in the Central Medial Thalamus Precedes Changes in the Neocortex during Transitions into Both Sleep and Propofol Anesthesia. J Neurosci. 2014 Oct 1;34(40):13326-35. doi: 10.1523/JNEUROSCI.1519-14.2014.
  Scriba MF, Rattenborg NC, Dreiss AN, Vyssotski AL, Roulin A. (2014) Sleep and vigilance linked to melanism in wild barn owls. J Evol Biol. 2014 Jul 24. doi: 10.1111/jeb.12450.
  Voirin B, Scriba MF, Martinez-Gonzalez D, Vyssotski AL, Wikelski M, Rattenborg NC. (2014) Ecology and neurophysiology of sleep in two wild sloth species. Sleep. 2014 Apr 1;37(4):753-61. doi: 10.5665/sleep.3584.
  Amendola E , Zhan Y , Mattucci C , Castroflorio E , Calcagno E , Fuchs C , Lonetti G , Silingardi D , Vyssotski A L , Farley D , Ciani E , Pizzorusso T , Giustetto M , Gross C T. (2014) Mapping pathological phenotypes in a mouse model of CDKL5 disorder. PLoS One. 2014 May 16;9(5):e91613. doi: 10.1371/journal.pone.0091613. eCollection 2014.
  Gelegen C., Gent T.C., Ferretti V., Zhang Z., Yustos R., Lan F., Yang Q., Overington D.W., Vyssotski A.L., van Lith H.A., Wisden W., Franks N.P. (2014) Staying awake--a genetic region that hinders α2 adrenergic receptor agonist-induced sleep. Eur J Neurosci. 2014 Jul;40(1):2311-9. doi: 10.1111/ejn.12570. Epub 2014 Mar 27.[ Supporting Information ]
  Zhan Y., Paolicelli R.C., Sforazzini F., Weinhard L., Bolasco G., Pagani F., Vyssotski A.L., Bifone A., Gozzi A., Ragozzino D., Gross C.T. (2014) Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior. Nat. Neurosci. 02 February 2014 | doi:10.1038/nn.3641 [ Supporting Information ]
  Duriez O., Kato A., Tromp C., Dell'omo G., Vyssotski A.L., Sarrazin F., Ropert-Coudert Y. (2014) How cheap is soaring flight in raptors? A preliminary investigation in freely-flying vultures. PLoS One. 9(1):e84887.
[ Supplementary Information ] [Google Earth: Sample Flight Path]
2013 Scriba M.F., Ducrest A.L., Henry I., Vyssotski A.L., Rattenborg N.C., Roulin A. (2013) Linking melanism to brain development: expression of a melanism-related gene in barn owl feather follicles covaries with sleep ontogeny. Front Zool. 10(1):42.
  Lewandowski B, Vyssotski A, Hahnloser RH, Schmidt M. (2013) At the interface of the auditory and vocal motor systems: NIf and its role in vocal processing, production and learning. J Physiol Paris. 2013 Jun;107(3):178-92.
  Scriba M.F., Harmening W.M., Mettke-Hofmann C., Vyssotski A.L., Roulin A., Wagner H., Rattenborg N.C. (2013) Evaluation of two minimally invasive techniques for electroencephalogram recording in wild or freely behaving animals. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 199(3):183-9.
  Scheffzük C., Kukushka V.I., Vyssotski A.L., Draguhn A., Tort A.B., Brankačk J. (2013) Global slowing of network oscillations in mouse neocortex by diazepam. Neuropharmacology. 65:123-33.
2012 Zecharia A.Y., Yu X., Götz T., Ye Z., Carr D.R., Wulff P., Bettler B., Vyssotski A.L., Brickley S.G., Franks N.P., and Wisden W. (2012) GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness. J. Neurosci. 32(38):13062-13075.
  Sachs G., Traugott J., Nesterova A.P., Dell'omo G., Kümmeth F., Heidrich W., Vyssotski A.L., and Bonadonna F. (2012) Flying at no mechanical energy cost: disclosing the secret of wandering albatrosses. PLoS One. 7(9):e41449. [ Supplemental Text ] [Google Earth: Wandering Albatross Dynamic Soaring]
  Lesku J.A., Rattenborg N.C., Valcu M., Vyssotski A.L., Kuhn S., Kuemmeth F., Heidrich W., and Kempenaers B. (2012) Adaptive sleep loss in polygynous pectoral sandpipers. Science. 2012 Aug 9. [ Supplemental Text ] [ Supplemental Movie ] [ Supplemental Audio ] [ Supplemental Database ]
  Brankačk J., Scheffzük C., Kukushka V.I., Vyssotski A.L., Tort A.B., and Draguhn A. (2012) Distinct features of fast oscillations in phasic and tonic rapid eye movement sleep. J Sleep Res. 2012 Jul 20. doi: 10.1111/j.1365-2869.2012.01037.x.
  Lyamin O.I., Kosenko P.O., Vyssotski A.L., Lapierre J.L., Siegel J.M., and Mukhametov LM. (2012) Study of sleep in a walrus. Dokl Biol Sci., 444:188-91.
2011 Scheffzük C., Kukushka V.I., Vyssotski A.L., Draguhn A., Tort A.B.L. and Brankack J. (2011) Selective coupling between theta phase and neocortical fast gamma oscillations during REM-sleep in mice. PLoS One, 6(12):e28489. [ Figures S1 - S6 ] [ Supplemental Text ]

Lesku J.A., Meyer L.C., Fuller A., Maloney S.K., Dell'Omo G., Vyssotski A.L. and Rattenborg N.C. (2011) Ostriches sleep like platypuses. PLoS One, 6(8):e23203. [ Figure S1 ] [ Figure S2 ] [ Supplemental Movie ] [ Supplemental Text ]

  Tsoar A., Nathan R., Bartan Y., Vyssotski A., Dell'Omo G. and Ulanovsky N. (2011) Large-scale navigational map in a mammal. Proc Natl Acad Sci USA, 108(37): E718-E724. [ Summary ] [ Supplemental Data ] [ Supplemental Movie ] [ Commentary by Edvard I. Moser ]
  Daan S., Spoelstra K., Albrecht U., Schmutz I., Daan M., Daan B., Rienks F., Poletaeva I., Dell'Omo G., Vyssotski A., and Lipp H.-P. (2011) Lab mice in the field: unorthodox daily activity and effects of a dysfunctional circadian clock allele. J Biol Rhythms, 26(2): 118-29. [ Supplemental Data ]

Lesku J.A., Vyssotski A.L., Martinez-Gonzalez D., Witzeck C., and Rattenborg N.C. (2011) Local sleep homeostasis in the avian brain: convergence of sleep function in mammals and birds? Proc Biol Sci. 278: 2419-28. [ Supplemental Data ]

2010 Brankack J., Kukushka V.I., Vyssotski A.L., and Draguhn A. (2010) EEG gamma frequency and sleep-wake scoring in mice: Comparing two types of supervised classifiers. Brain Res. 1322: 59-71
2009 Pang D.S., Robledo C.J., Carr D.C., Gent T.C., Vyssotski A.L., Caley A, Zecharia A., Wisden W., Brickley S.G., and Franks N.P. (2009) An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action. Proc Natl Acad Sci USA, 106(51): 17546-17551

Vyssotski A.L., Dell'Omo G., Dell'Ariccia G., Abramchuk A.N., Serkov A.N., Latanov A.V., Loizzo A., Wolfer D.P., and Lipp H.-P. (2009) EEG responses to visual landmarks in flying pigeons. Curr Biol. 19(14): 1159-1166.
[ Supplemental Data ] Publicity: Science NOW

2008 Traugott J., Dell'Omo G., Vyssotski A.L., Odijk D., and Sachs D. (2008) A time-relative approach for precise positioning with a miniaturized L1 GPS logger. ION GNSS 21st International Technical Meeting of Satellite Division, 16-19, September 2008, Savannah, GA: 1883-1894
  Rattenborg N.C., Voirin B., Vyssotski A.L., Kays R.W., Spoelstra K., Kuemmeth F., Heidrich W.,and Wikelski M. (2008) Sleeping outside the box: electroencephalographic measures of sleep in sloths inhabiting a rainforest.
Biol Lett. 4(4): 402-5.
[ Supplemental Data ] Publicity: Science NOW
  Ben Abdallah N.M., Slomianka L., Vyssotski A.L., and Lipp H.-P. (2008) Early age-related changes in adult hippocampal neurogenesis in C57 mice, Neurobiol Aging, doi:10.1016/j.neurobiolaging.2008.03.002
2006 Vyssotski A.L., Serkov A.N., Itskov P.M., Dell'Omo G., Latanov A.V., Wolfer D.P., and Lipp H.-P. (2006) Miniature neurologgers for flying pigeons: multichannel EEG and action and field potentials in combination with GPS recording. J Neurophysiol 95: 1263-1273. [ Journal Cover ]
2005 Galsworthy M.J., Amrein I., Kuptsov P.A., Poletaeva I.I., Zinn P., Rau A.E., Vyssotski A.L., and Lipp H.-P. (2005) A comparison of wild-caught wood mice and bank voles in the Intellicage: assessing exploration, daily activity patterns and place learning paradigms. Behavioural Brain Research, 157(2), 211-217
2004 Lipp, H.-P., Vyssotski, A.L., Wolfer, D.P., Renaudineau, S., Savini, M., Tröster, G., and Dell'Omo, G. (2004). Pigeon homing along highways and exits. Curr.Biol. 14(14), 1239-1249. [ Supplemental Data ] [ Journal Cover ]
  Lewejohann, L., Skryabin, B.V., Sachser, N., Prehn, C., Heiduschka, P., Thanos, S., Jordan, U., Vyssotski, A.L., Pleskacheva, M.G., Lipp, H.-P. et al. (2004). Role of a neuronal small non-messenger RNA: behavioural alterations in BC1 RNA-deleted mice. Behav. Brain Res. 154(1), 273-289.
2002 Vyssotski, A.L., Dell'Omo, G., Poletaeva, I.I., Vyssotski, D.L., Minichiello, L., Klein, R., Wolfer, D.P., and Lipp, H.-P. (2002). Long-term monitoring of hippocampus-dependent behavior in naturalistic settings: mutant mice lacking the neurotrophin receptor TrkB in the forebrain show spatial learning but impaired behavioral flexibility. Hippocampus 12, 27-38.
  Dell'Omo, G., Vannoni, E., Vyssotski, A.L., Di Bari, M.A., Nonno, R., Agrimi, U., and Lipp, H.-P. (2002). Automated home cage monitoring of mice infected with BSE and scrapie differentiates early behavioural changes according to prion strain. European Journal of Neuroscience 16, 735-742.
1999 Vysotskii A.L., Vysotskii D.L., Gudasheva T.A., Ostrovskaya R.U., Anokhin K.V. (1999). Modulation of long-term memory by delayed administration of the Amide of L-Pyroglutamyl-D-alanine, a nootropic agent, in spaced and massed training in rats. – Neuroscience and Behavioral Physiology, 29(2), 137-142.
1996 Vysotskii A.L., Vysotskii D.L. (1996). Improved evaluation of the parameters of linearizable relationships. - Biophysics, 41(3), 775-777.

© 2017 Alexei Vyssotski